Serum thyroglobulin antibody levels within or near to the reference range may interfere with thyroglobulin measurement

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Serum thyroglobulin antibody levels within or near to the reference range may interfere with thyroglobulin measurement

High concentration of thyroglobulin antibodies (TgAb) is a major limiting factor of thyroglobulin measurements in patients with differentiated thyroid cancer. We investigated whether thyroglobulin antibody added to serum samples could interfere with the thyroglobulin assay. Thyroglobulin levels in serum samples with different concentrations of thyroglobulin were measured by electrochemiluminesc...

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Preoperative determination of serum thyroglobulin to identify patients with differentiated thyroid cancer who may present recurrence without increased thyroglobulin.

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[Serum thyroglobulin levels in patients with thyroid tumor].

Serum thyroglobulin (Tg) levels were measured in 15 normal volunteers, 69 patients with differentiated thyroid carcinoma, 22 with adenoma, 45 with adenomatous goiter, 5 with functioning adenoma and 24 with Graves' disease, utilizing a double antibody radioimmunoassay technique. Serum Tg levels in the normal volunteers were found to be less than 30 ng/ml as determined from their mean value, i.e....

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Estimation of True Serum Thyroglobulin Concentration Using Simultaneous Measurement of Serum Antithyroglobulin Antibody

We investigated the analytical interference of antithyroglobulin antibody (TgAb) to thyroglobulin (Tg) measurement and tried to convert measured Tg concentration to true Tg concentration using a mathematical equation which includes a concentration of TgAb. Methods. Tg was measured by immunoradiometric assay and TgAb by radioimmunoassy. Experimental samples were produced by mixing Tg and TgAb st...

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ژورنال

عنوان ژورنال: Biochemia Medica

سال: 2012

ISSN: 1846-7482

DOI: 10.11613/bm.2012.038